| TOA, USA | Stamping, Welding, Coating, Assembly | Mooresville | 1,000 +/- |
| Franciscan Health Mooresville | Full Service Medical Care | Mooresville | 425 |
| Nice-Pak Products Inc. | Personal care wipes for leading retailers and own brands: Nice N’ Clean, Grime Boss and Wet-Nap | Mooresville | 413 |
| IU Health Morgan | Full Service Medical Care | Martinsville | 265 |
| PacMoore | Blending, spray drying, extrusion, consumer packaging, re-packaging, sifting, bulk loading & unloading, tolling solutions, research & development, ingredient storage, warehousing, shipping, turnkey solutions | Mooresville | 166 |
| FBF Originals | Leading manufacturer, distributor, and retailer of licensed and novelty socks | Martinsville | 115 |
| Creative Foam (Mt. Olive Manufacturing) | Contract manufacturing, RF welding/dielectric sealing expertise, engineering and tooling design, and prototyping and testing | Mooresville | 115 |
| General Shale | Manufacturer of building materials: building stone, bricks, mortar, sand, crushed brick & rocks, lintels & covers | Mooresville | 102 |
| Equipment Technologies | Manufacturer of Apache Sprayers | Mooresville | 94 |
| Linel | Provider of premium architectural products | Mooresville | 94 |
| Thiesing Veneer Co. | Face veneers from major species like Oak, Walnut, Maple, Birch, Poplar, Hickory and Cherry | Mooresville | 90 |
| Molex | Manufacturer of electronic components | Mooresville | 75 |
| Creative Works | Manufacturer of entertainment products such as laser tag, escape rooms, cosmic golf, lucky putt golf, virtual reality, etc. | Mooresville | 70 |
| Twigg Corpoartion | Creates 3D solid modeling, weldments, large assembly design, sheet metal design, mold design, piping and tubing, electrical cable harness and conduit design, plastic and cast part design, and CAD import/export | Martinsville | 65 |
| Capital Adhesive & Packaging | Manufacturer of custom adhesive products | Mooresville | 57 |
| Overton Industries | Tool & Die- from small high speed dies to the larger blanking dies to production capabilities | Mooresville | 51 |
| FloSource | Distributor of valve, actuation, instrumentation and steam equipment for end-users, OEMs, Engineering and Construction Services (E&Cs), as well as process mechanical contractors in power, oil, gas, food and beverage, chemical, pharmaceutical, plastics, steel and water/waste management | Mooresville | 38 |
| Crone Lumber | | Martinsville | 37 |
| Harris Rebar | Manufacturer of construction products such as rebar fabrication, wire mesh, anchor bolts, mechanical couplers, Vulcraft steel roof and floor decking | Mooresville | 36 |
| Form/Tec Plastics | Formed and Post-coated optical polycarbonate & acrylic | Martinsville | 35 |
| Matchless Machine & Tool Co | Designers and builders of plastic injection molds since 1977 | Martinsville | 28 |
| Sun Polymers International | Eco-friendly, high performance resins for powder coating | Mooresville | 25 |
| Advance Aero | Aircraft Maintenance, Repair and Overhaul (MRO) Services, Aircraft Fabrication and Modification, Finishing | Mooresville | 20 |
| Powder Pro Coating | Powder coating, sandblasting, welding & fabrication, liquid coating, ceramic coating, restoration and more | Mooresville | 18 |
| Oliver Machine & Tool Corp | Customer waterjet cutting, precision CNC machining, wire EDM, inspection & metrology and more | | 15 |
| Jacobs Machine & Tool | Ram and wire EDM machining, precision stamping dies, rollform tooling and general and CNC milling | Mooresville | 14 |
| Structural Components Fabrication | Steel framing and structures, stairs and railings and special projects and ornamental metalwork | | 14 |
| DRP Mold | Full-service rubber tooling | Martinsville | 13 |
| MAB Commercial Glazing | Commercial glasswork | Martinsville | 10 |
| Thermocore Panel Systems | SIP Products: insulated wall and roof panels | Mooresville | 8 |
| MTEK Weapon Systems | Military-grade armor manufacturer specializing in ballistic and carbon helmets and accessories | Martinsville | 7 |
| J W Jones | Offers equipment, engineering, fabrication, field installation, parts and services | Martinsville | 6 |
| Martin Merietta | Produces aggregates, asphalt, magnesia chemicals and lime, cement and cement treated materials | Mooresville | 6 |
| Hopkins & Woods | Machine shop | Martinsville | 5 |
| Ace Tool & Engineering | Mandrill welding, end arm tooling, machine guarding, plastic trim dies and more | Mooresville | 2 |
